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SHR Neuro Cancer Cardio Lipid Metab Microb
Geier, J; Schubert, S; Schnuch, A; Szliska, C; Weisshaar, E; Kränke, B; Werfel, T; Ruëff, F; Schröder-Kraft, C; Buhl, T, , Information, Network, of, Departments, of, Dermatology.
A negative breakdown test in a fragrance mix I-positive patient does not rule out contact allergy to its fragrance constituents.
Contact Dermatitis. 2021; 84(6):407-418
Doi: 10.1111/cod.13803
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Kränke Birger
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- Abstract:
- BACKGROUND: In about half of the patients reacting positive to fragrance mix I (FM I), breakdown testing remains negative. This raises the question of whether the reaction to FM I is false-positive, or the breakdown test is false-negative. OBJECTIVES: To identify characteristics and sensitization patterns of patients positive to FM I, but not to its fragrance constituents. PATIENTS AND METHODS: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK) between 2005 and 2019. Three patient groups were defined according to their reaction pattern: Group I, FM I positive and ≥1 single fragrance positive in the breakdown test (n = 1912); Group II, FM I positive and breakdown test negative (n = 1318); Group III, FM I negative (n = 19 790). RESULTS: Regarding the pattern of concomitant reactions to other fragrances, Group II had an intermediate position between Group I and Group III. In other respects (age and sex distribution, frequency of sensitization to non-fragrance baseline series allergens), Group II rather resembled Group I. CONCLUSIONS: Not every positive reaction to FM I in patients with negative breakdown tests is false-positive. There may be false-negative reactions to the single fragrance components when patch tested at 1% pet. Raising patch concentrations of some single fragrances is recommended.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Dermatitis, Allergic Contact - diagnosis
- Dermatitis, Atopic - diagnosis
- Dermatitis, Occupational - diagnosis
- False Negative Reactions - administration & dosage
- False Positive Reactions - administration & dosage
- Hand Dermatoses - diagnosis
- Humans - administration & dosage
- Leg Dermatoses - diagnosis
- Male - administration & dosage
- Odorants - administration & dosage
- Patch Tests - methods
- Retrospective Studies - administration & dosage
- Find related publications in this database (Keywords)
- amyl cinnamal
- breakdown test
- clinical epidemiology
- eugenol
- fragrance allergy
- fragrance mix I
- geraniol
- patch test concentration
- patch testing