Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reitermaier, R; Krausgruber, T; Fortelny, N; Ayub, T; Vieyra-Garcia, PA; Kienzl, P; Wolf, P; Scharrer, A; Fiala, C; Kölz, M; Hiess, M; Vierhapper, M; Schuster, C; Spittler, A; Worda, C; Weninger, W; Bock, C; Eppel, W; Elbe-Bürger, A.
αβγδ T cells play a vital role in fetal human skin development and immunity.
J Exp Med. 2021; 218(4):
Doi: 10.1084/jem.20201189
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- Co-Autor*innen der Med Uni Graz
- Vieyra Garcia Pablo Augusto
- Wolf Peter
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- Abstract:
- T cells in human skin play an important role in the immune defense against pathogens and tumors. T cells are present already in fetal skin, where little is known about their cellular phenotype and biological function. Using single-cell analyses, we identified a naive T cell population expressing αβ and γδ T cell receptors (TCRs) that was enriched in fetal skin and intestine but not detected in other fetal organs and peripheral blood. TCR sequencing data revealed that double-positive (DP) αβγδ T cells displayed little overlap of CDR3 sequences with single-positive αβ T cells. Gene signatures, cytokine profiles and in silico receptor-ligand interaction studies indicate their contribution to early skin development. DP αβγδ T cells were phosphoantigen responsive, suggesting their participation in the protection of the fetus against pathogens in intrauterine infections. Together, our analyses unveil a unique cutaneous T cell type within the native skin microenvironment and point to fundamental differences in the immune surveillance between fetal and adult human skin. © 2021 Reitermaier et al.