Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Radosinska, J; Jasenovec, T; Puzserova, A; Krajcir, J; Lacekova, J; Kucerova, K; Kalnovicova, T; Tothova, L; Kovacicova, I; Vrbjar, N.
Promotion of whole blood rheology after vitamin C supplementation: focus on red blood cells 1.
Can J Physiol Pharmacol. 2019; 97(9):837-843
Doi: 10.1139/cjpp-2018-0735
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- Di Rosso Jana
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- Abstract:
- Hemorheological properties represent significant contributors in the pathogenesis of cardiovascular diseases. As plasma vitamin C is inversely associated with blood viscosity in humans, we aimed to characterize the effect of vitamin C supplementation on hemorheology with an emphasis on erythrocyte functions. Twenty young healthy volunteers were asked to take vitamin C (1000 mg per day) for 3 weeks. We observed beneficial effect of intervention on multiple hemorheological parameters: whole blood viscosity in the range of medium to high shear rates, Casson yield stress, complex viscosity, and storage and loss moduli. As erythrocyte properties play a significant role in hemorheology, we characterized their deformability, nitric oxide production, and sodium pump activity in erythrocyte membranes. We can conclude that observed promotion in whole blood rheology may be consequence of improved erythrocyte functionality as concerns their ability to pass through narrow capillaries of the microcirculation, nitric oxide production, and sodium pump activity. Parameters reflecting oxidative stress and antioxidant status in plasma were not affected by our intervention. As improvement in hemorheology may play an important role in cardioprotection, it would be challenging to investigate the vitamin C supplementation to patients suffering from microcirculatory disturbances and worsened organ perfusion in the case of cardiovascular diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Ascorbic Acid - pharmacology
- Dietary Supplements -
- Erythrocyte Deformability - drug effects
- Erythrocyte Membrane - drug effects
- Erythrocyte Membrane - metabolism
- Erythrocytes - cytology
- Erythrocytes - drug effects
- Erythrocytes - metabolism
- Female -
- Hemorheology - drug effects
- Humans -
- Male -
- Nitric Oxide - biosynthesis
- Oxidation-Reduction - drug effects
- Sodium-Potassium-Exchanging ATPase - metabolism
- Young Adult -
- Find related publications in this database (Keywords)
- ascorbic acid
- hemorheology
- blood viscosity
- yield stress
- erythrocytes
- erythrocyte deformability
- nitric oxide
- sodium pump
- oxidative stress