Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Teufelberger, AR; Bröker, BM; Krysko, DV; Bachert, C; Krysko, O.
Staphylococcus aureus Orchestrates Type 2 Airway Diseases.
Trends Mol Med. 2019; 25(8): 696-707.
Doi: 10.1016/j.molmed.2019.05.003
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Teufelberger Andrea Renate
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- Abstract:
- Staphylococcus aureus persistently colonizes the nostrils of one-third of the population but colonizes the sinus mucosa in up to 90% of patients with nasal polyps, implying a possible role in airway disease. Recent findings give new mechanistic insights into the ability of S. aureus to trigger type 2 inflammatory responses in the upper and lower airways. This novel concept of a S. aureus-driven chronic airway inflammatory disease suggests a new understanding of disease triggers. This article reviews the role of S. aureus in chronic inflammatory airway diseases and discusses possible therapeutic approaches to target S. aureus. Copyright © 2019 Elsevier Ltd. All rights reserved.
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