Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Simic, A; Schøndorff, PK; Stumpe, T; Heschel, M; Regittnig, W; Pöttler, T; Ninaus, D; Augustin, T; Groselj-Strele, A; Pieber, TR; Mader, JK, ;on behalf of the Hypo-RESOLVE, Consortium;AiDAPT, AP@home04, CLOuD, DAN05, DAN06, and, KidsAP, consortia;HYPO-RESOLVE, Consortium;KidsAP, Consortium.
Survival assessment of the extended-wear insulin infusion set featuring lantern technology in adults with type 1 diabetes by the glucose clamp technique.
Diabetes Obes Metab. 2021; 23(6):1402-1408
Doi: 10.1111/dom.14337
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- Führende Autor*innen der Med Uni Graz
- Mader Julia
- Simic Amra
- Co-Autor*innen der Med Uni Graz
- Groselj-Strele Andrea
- Ninaus Daniela
- Pieber Thomas
- Pöttler Tina
- Regittnig Werner
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- Abstract:
- Maintaining good glycaemic control with the same infusion set for longer than 3 days may improve the quality of life of insulin pump users. The aim of the current study was to assess the efficacy and safety of the novel, extended-wear infusion set over 7 days of wear in adults with type 1 diabetes. Sixteen participants completed three identical 8-hour euglycaemic clamp experiments on Days 1, 4 and 7 of infusion set wear. Between the experiments, the participants were discharged home for routine diabetes management while wearing the same extended-wear infusion set throughout the study. Time to reach the maximum glucose infusion rate (TGIRmax ) on Day 7 was reduced by 67% compared with Day 1 (p < .001). The corresponding area under the glucose infusion rate curve (AUCGIR ) was comparable for the first 2 h of the clamp (p = .891) but decreased by 28% over time (p < .008). While the extent of insulin absorption decreased with prolonged wear, it was accompanied by an increase in insulin absorption rate. The infusion set survival rate was 100% without leakages, occlusion alarms, severe hypoglycaemia or ketoacidosis. The extended-wear infusion set proved safe and effective during prolonged wear in real-life conditions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Blood Glucose - administration & dosage
- Diabetes Mellitus, Type 1 - drug therapy
- Glucose Clamp Technique - administration & dosage
- Humans - administration & dosage
- Hypoglycemic Agents - therapeutic use
- Insulin - therapeutic use
- Insulin Infusion Systems - administration & dosage
- Quality of Life - administration & dosage
- Technology - administration & dosage
- Find related publications in this database (Keywords)
- clinical trial
- CSII
- insulin pump therapy
- pharmacodynamics
- pharmacokinetics
- type 1 diabetes