Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Lajin, B; Francesconi, KA.
The hydrogen sulfide metabolite trimethylsulfonium is found in human urine.
Sci Rep. 2016; 6(8):27038-27038
Doi: 10.1038/srep27038
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- Leading authors Med Uni Graz
- Lajin Bassam
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- Abstract:
- Hydrogen sulfide is the third and most recently discovered gaseous signaling molecule following nitric oxide and carbon monoxide, playing important roles both in normal physiological conditions and disease progression. The trimethylsulfonium ion (TMS) can result from successive methylation reactions of hydrogen sulfide. No report exists so far about the presence or quantities of TMS in human urine. We developed a method for determining TMS in urine using liquid chromatography-electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-QQQ), and applied the method to establish the urinary levels of TMS in a group of human volunteers. The measured urinary levels of TMS were in the nanomolar range, which is commensurate with the steady-state tissue concentrations of hydrogen sulfide previously reported in the literature. The developed method can be used in future studies for the quantification of urinary TMS as a potential biomarker for hydrogen sulfide body pools.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biomarkers - urine
- Calibration -
- Chromatography, Liquid - methods
- Chromatography, Liquid - standards
- Female -
- Healthy Volunteers -
- Humans -
- Hydrogen Sulfide - urine
- Male -
- Middle Aged -
- Reference Standards -
- Spectrometry, Mass, Electrospray Ionization - methods
- Spectrometry, Mass, Electrospray Ionization - standards
- Sulfonium Compounds - urine