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SHR Neuro Cancer Cardio Lipid Metab Microb
Lajin, B; Alachkar, A; Hamzeh, AR; Michati, R; Alhaj, H.
No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population.
N Am J Med Sci. 2011; 3(4):176-178
Doi: 10.4297/najms.2011.3176
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- Leading authors Med Uni Graz
- Lajin Bassam
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- Abstract:
- The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. The aim of the present study was to investigate possible association between schizophrenia and Val158Met in a novel Arab population from Syria. 71 unrelated schizophrenic subjects (45 men) and 102 unrelated healthy controls (62 men) were recruited to take part in this case- control study. The Val158Met of the COMT gene was genotyped for patients and controls, using a new optimized PCR-RFLP method. the results demonstrated that there is no statistically significant difference between the two groups. This study does not support that Val158Met has an influence on susceptibility for schizophrenia in this population.