Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bacsa, B; Tiapko, O; Stockner, T; Groschner, K.
Mechanisms and significance of Ca2+ entry through TRPC channels.
Curr Opin Physiol. 2020; 17(2):25-33
Doi: 10.1016/j.cophys.2020.06.005
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- Führende Autor*innen der Med Uni Graz
- Bacsa Bernadett
- Groschner Klaus
- Co-Autor*innen der Med Uni Graz
- Tiapko Oleksandra
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- Abstract:
- The transient receptor potential (TRP) superfamily of plasma membrane cation channels has been recognized as a signaling hub in highly diverse settings of human physiopathology. In the past three decades of TRP research, attention was focused mainly on the channels Ca2+ signaling function, albeit additional cellular functions, aside of providing a Ca2+ entry pathway, have been identified. Our understanding of Ca2+ signaling by TRP proteins has recently been advanced by a gain in high-resolution structure information on these pore complexes, and by the development of novel tools to investigate their role in spatiotemporal Ca2+ handling. This review summarizes recent discoveries as well as remaining, unresolved aspects of the canonical subfamily of transient receptor potential channels (TRPC) research. We aim at a concise overview on current mechanistic concepts of Ca2+ entry through- and Ca2+ signaling by TRPC channels.