Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eckstein, ML; Moser, O; Tripolt, NJ; Pferschy, PN; Obermayer, AAM; Kojzar, H; Mueller, A; Abbas, F; Sourij, C; Sourij, H.
Rapid glucose rise reduces heart rate variability in adults with type 1 diabetes: A prospective secondary outcome analysis.
Diabetes Obes Metab. 2021; 23(7):1681-1684
Doi: 10.1111/dom.14287
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Eckstein Max Lennart
- Moser Othmar
- Co-Autor*innen der Med Uni Graz
- Abbas Farah
- Kojzar Harald
- Müller Alexander
- Pferschy Peter
- Ramirez-Obermayer Anna Maria Antonia
- Sourij Caren
- Sourij Harald
- Tripolt Norbert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- To investigate differences in heart rate variability (HRV) during oral glucose tolerance tests (OGTTs) in response to the rate of change in glucose and to different glycaemic ranges in individuals with type 1 diabetes. This was a single-centre, prospective, secondary outcome analysis in 17 individuals with type 1 diabetes (glycated haemoglobin 53 ± 6.3 mmol/L), who underwent two OGTTs (after 12 and 36 hours of fasting) investigating differences in HRV in response to rapid glucose increases/decreases and different glycaemic ranges during OGTT. Based on the rate of change in glucose level, the variables heart rate (P < 0.001), square root of the mean standard difference of successive R-R intervals (P = 0.002), percentage of pairs of R-R intervals with >50 ms difference (P < 0.001) and corrected QT interval (P = 0.04) were significantly altered, with HRV particularly reduced during episodes of rapid glucose rises. Glycaemic ranges during OGTT had no impact on HRV (P < 0.05). Individuals with type 1 diabetes showed no changes in HRV in response to different glycaemic ranges. HRV was dependent on the rate of change in glucose, especially rapid increases in glucose level.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Autonomic Nervous System - administration & dosage
- Diabetes Mellitus, Type 1 - drug therapy
- Glucose - administration & dosage
- Heart Rate - administration & dosage
- Humans - administration & dosage
- Prospective Studies - administration & dosage
- Find related publications in this database (Keywords)
- autonomic regulation
- heart rate variability
- oral glucose tolerance test
- type 1 diabetes