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SHR Neuro Cancer Cardio Lipid Metab Microb
Kastnerova, L; Belousova, IE; Hadravsky, L; Kerl, H; Cerroni, L; Kerl, K; Boudova, L; Jindra, P; Cerna, K; Michal, M; Kazakov, DV.
Mummified Cells are a Common Finding in Cutaneous Hodgkin Lymphoma and Can Be Used as a Diagnostic Clue.
Am J Dermatopathol. 2020; 42(1): 24-28.
Doi: 10.1097/DAD.0000000000001445
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- Specific cutaneous involvement in Hodgkin lymphoma is rare. In cutaneous lesions, the diagnosis is usually based on the recognition of diagnostic Reed-Sternberg cells and its variants. In nodal Hodgkin lymphoma, so-called mummified cells (cells with condensed cytoplasm and pyknotic eosinophilic or basophilic nuclei) are often seen. They are sometimes conspicuous and easy to recognize, thus serving as a clue to the diagnosis. Our objective was to study cases of cutaneous Hodgkin lymphoma to identify the occurrence of mummified cells. We studied 12 patients (4 women and 8 men; age range 23-80 years). In 6 patients, cutaneous and extracutaneous disease was identified almost simultaneously; in 4 patients, lymph node disease preceded cutaneous involvement; and in the remaining 2 patients, the skin lesions were the presenting sign, whereas lymph node involvement occurred later. Histopathological, immunohistochemical, and molecular-genetic studies, including rearrangements for TCR, IgH genes, and PCR for EBV, were performed. Cutaneous biopsy specimens revealed either a multinodular or diffuse infiltrate, included small lymphocytes, eosinophils, plasma cells, and macrophages, but in all cases, diagnostic Reed-Sternberg cells and its variants were identified. Mummified cells were detected in 9 cases, either as occasional scattered mummified cells often requiring a search (6 cases) or being conspicuous, grouped and therefore easily identified (3 cases). Immunohistochemically, in all 7 cases studied, mummified cells were positive for both CD30 and CD15. It is concluded that mummified cells are encountered in a majority of cases of cutaneous Hodgkin lymphoma.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Female -
- Hodgkin Disease - pathology
- Humans -
- Male -
- Middle Aged -
- Skin Neoplasms - pathology
- Young Adult -
- Find related publications in this database (Keywords)
- cutaneous Hodgkin
- lymphoma
- mummified cells
- CD30