Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Scheipner, L; Smolle, MA; Barth, D; Posch, F; Stotz, M; Pichler, M; StÖger, H; Gerger, A; Riedl, JM.
The AST/ALT Ratio Is an Independent Prognostic Marker for Disease-free Survival in Stage II and III Colorectal Carcinoma.
Anticancer Res. 2021; 41(1):429-436
Doi: 10.21873/anticanres.14792
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Gerger Armin
- Scheipner Lukas
- Co-Autor*innen der Med Uni Graz
- Barth Dominik Andreas
- Pichler Martin
- Posch Florian
- Riedl Jakob
- Smolle Maria Anna
- Stöger Herbert
- Stotz Michael
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- Abstract:
- BACKGROUND/AIM: The Aspartate aminotransaminase/Alanine aminotransaminase ratio (AST/ALT ratio) has been identified as a prognostic marker for several malignancies. In this study, we evaluated the prognostic value of the AST/ALT ratio in a large cohort of non-metastatic colorectal cancer patients (CRC). PATIENTS AND METHODS: A total of 536 patients with stage II and III CRC, as well as available AST/ALT ratio were included in this single-center retrospective analysis. Laboratory data were measured within two weeks before histological tumor diagnosis. Co-Primary endpoints for this analysis were disease-free survival (DFS) and overall survival (OS). RESULTS: In univariate cox regression DFS was significantly shorter in patients with an elevated AST/ALT ratio (HR=1.568, 95%CI=1.10-2.23, p=0.012). In multivariable analysis, the prognostic association between an elevated AST/ALT ratio and a poor survival prevailed statistically significant (HR=1.53, 95%C=1.05-2.22, p=0.026). No statistically significant association between the AST/ALT ratio and OS was observed (HR=1.4, 95% CI=0.89-2.22, p=0.14). CONCLUSION: In this study, the serum AST/ALT ratio emerged as a valid prognostic marker for DFS in non-metastatic colorectal cancer patients at stage II and III.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Alanine Transaminase - blood
- Aspartate Aminotransferases - blood
- Biomarkers, Tumor - administration & dosage
- Colorectal Neoplasms - blood, diagnosis, mortality, therapy
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Neoplasm Grading - administration & dosage
- Neoplasm Metastasis - administration & dosage
- Neoplasm Staging - administration & dosage
- Prognosis - administration & dosage
- Proportional Hazards Models - administration & dosage
- Retrospective Studies - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- Colorectal cancer
- AST/ALT ratio
- prognosis
- disease free survival
- transaminases