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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Enko, D; Zelzer, S; Wenninger, J; Holasek, S; Schnedl, WJ; Baranyi, A; Herrmann, M; Meinitzer, A.
Interleukin-6 is associated with tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption.
EXCLI J. 2020; 19(23):1414-1422
Doi: 10.17179/excli2020-2940
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- Leading authors Med Uni Graz
- Enko Dietmar
- Co-authors Med Uni Graz
- Baranyi Andreas
- Herrmann Markus
- Holasek Sandra Johanna
- Meinitzer Andreas
- Schnedl Wolfgang
- Wenninger Julian
- Zelzer Sieglinde
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- Abstract:
- The aim of the present study was to investigate possible associations between interleukin-6 (IL-6), interferon-gamma (INF-γ), tumor necrosis factor-alpha (TNF-α), lactoferrin and lipopolysaccharide binding protein (LBP) with TRP metabolism and signs of depression in a large cohort of outpatients referred for carbohydrate malabsorption testing. Serum concentrations of IL-6, INF-γ, TNF-α, lactoferrin, LBP, tryptophan (TRP), kynurenine (KYN) and kynuric acid were determined in 250 adults referred for lactose and fructose malabsorption testing. All participants filled out the Beck Depression Inventory (BDI). Serum IL-6 levels were positively correlated with the BDI score (p = 0.001, ρ = 0.205) and indicators of TRP metabolism (KYN/TRP ratio, KYN) (P-values < 0.05, ρ = 0.176 and 0.136). Ninety-five individuals with a BDI score > 13 showed significantly higher IL-6 serum levels (1.7 [1.0 - 2.8] vs. 1.1 [0.8 - 1.7] pg/mL, p < 0.001) compared to 115 individuals with a BDI score ≤ 13. LBP showed a positive correlation with the KYN/TRP ratio (p = 0.005, ρ = 0.177). IL-6 and LBP were associated with indicators of TRP metabolism. IL-6 was found to be linked to signs of depression. Individuals with the presence of depressive symptoms showed higher serum IL-6 levels compared to individuals without depressive symptoms. Copyright © 2020 Enko et al.
- Find related publications in this database (Keywords)
- Depression
- inflammation
- interleukin-6
- interferon-gamma
- tumor necrosis factor-alpha
- lactoferrin