Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Riederer, M; Wallner, M; Schweighofer, N; Fuchs-Neuhold, B; Rath, A; Berghold, A; Eberhard, K; Groselj-Strele, A; Staubmann, W; Peterseil, M; Waldner, I; Mayr, JA; Rothe, M; Holasek, S; Maunz, S; Pail, E; van, der, Kleyn, M.
Distinct maternal amino acids and oxylipins predict infant fat mass and fat-free mass indices.
Arch Physiol Biochem. 2023; 129(3):563-574
Doi: 10.1080/13813455.2020.1846204
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Eberhard Katharina
- Groselj-Strele Andrea
- Holasek Sandra Johanna
- Schweighofer Natascha
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Interested in maternal determinants of infant fat mass index (FMI) and fat-free mass index (FFMI), considered as predictors for later development of obesity, we analysed amino acids (AA) and oxylipins in maternal serum and breast milk (BM). FMI and FFMI were calculated in 47 term infants aged 4 months (T4). Serum AA were analysed in pregnancy (T1, T2) and 6-8 weeks postpartum (T3). At T3, AA and oxylipins were analysed in BM. Biomarker-index-associations were identified by regression analysis. Infant FMI (4.1 ± 1.31 kg/m2; MW ± SD) was predicted by T2 proline (R2 adj.: 7.6%, p = .036) and T3 BM 11-hydroxy-eicosatetraenoic-acid (11-HETE) and 13-hydroxy-docosahexaenoic-acid (13-HDHA; together:35.5% R2 adj., p < .001). Maternal peripartum antibiotics (AB) emerged as confounders (+AB: 23.5% higher FMI; p = .025). Infant FFMI (12.1 ± 1.19 kg/m2; MW ± SD) was predicted by histidine (R2 adj.: 14.5%, p < .001) and 17-HDHA (BM, R2 adj.:19.3%, p < .001), determined at T3. Confirmed in a larger cohort, the parameters could elucidate connections between maternal metabolic status, nutrition, and infant body development.
- Find related publications in this database (using NLM MeSH Indexing)
- Female - administration & dosage
- Pregnancy - administration & dosage
- Humans - administration & dosage
- Infant - administration & dosage
- Oxylipins - administration & dosage
- Body Composition - administration & dosage
- Amino Acids - administration & dosage
- Child Development - administration & dosage
- Obesity - administration & dosage
- Amines - administration & dosage
- Hydroxy Acids - administration & dosage
- Body Mass Index - administration & dosage
- Find related publications in this database (Keywords)
- Infant body composition
- oxylipins
- amino acids
- fat mass index
- maternal biomarkers