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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schnedl, WJ; Holasek, SJ; Schenk, M; Enko, D; Mangge, H.
Diagnosis of hepatic nuclear factor 1A monogenic diabetes mellitus (HNF1A-MODY) impacts antihyperglycemic treatment.
Wien Klin Wochenschr. 2021; 133(5-6):241-244
Doi: 10.1007/s00508-020-01770-2
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Schnedl Wolfgang
- Co-authors Med Uni Graz
- Enko Dietmar
- Holasek Sandra Johanna
- Mangge Harald
- Schenk Michael
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- Abstract:
- Monogenic mutations of the hepatocyte nuclear factor 1 homeobox A maturity onset diabetes of the young (HNF1A-MODY) is characterized by early onset, typically before the age of 25 years. Patients are often not clinically recognized; however, the identification of HNF1A-MODY patients is crucial because they require different antihyperglycemic medical treatment than patients with type 1 or type 2 diabetes mellitus. We describe two adult patients with monogenic diabetes, both identified as HNF1A-MODY, genetically c.815G>A, p.Arg272His and c675delC, p.Ser225Argfs*8, respectively. They were misdiagnosed as having type 1 diabetes mellitus, and consequently, initiating insulin therapy led to hypoglycemia and unstable blood glucose control. Usually, sulfonylureas represent the basis of antidiabetic treatment in patients with HNF1A-MODY; however, all medical personnel involved in diabetes care should be aware of monogenic diabetes mellitus and the possibilities for genetic testing. The patients observed have shown the necessity of the identification and appropriate genetic diagnosis of HNF1A-MODY in order to discontinue insulin therapy and to initiate adjusted diabetes management.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Diabetes Mellitus, Type 1 - diagnosis
- Diabetes Mellitus, Type 1 - drug therapy
- Diabetes Mellitus, Type 1 - genetics
- Diabetes Mellitus, Type 2 - diagnosis
- Diabetes Mellitus, Type 2 - drug therapy
- Diabetes Mellitus, Type 2 - genetics
- Hepatocyte Nuclear Factor 1-alpha - genetics
- Humans -
- Hypoglycemic Agents - therapeutic use
- Mutation - genetics
- Sulfonylurea Compounds -
- Find related publications in this database (Keywords)
- Monogenic diabetes
- Hepatocyte nuclear factor
- 1
- Maturity onset of diabetes in the young
- Intensive insulin therapy
- Sulfonylureas