Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sánchez-Murcia, PA; de Castro, S; García-Aparicio, C; Jiménez, MA; Corona, A; Tramontano, E; Sluis-Cremer, N; Menéndez-Arias, L; Velázquez, S; Gago, F; Camarasa, MJ.
Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.
ACS Med Chem Lett. 2020; 11(5):811-817
Doi: 10.1021/acsmedchemlett.9b00623
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- Führende Autor*innen der Med Uni Graz
- Sánchez Murcia Pedro Alejandro
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- Abstract:
- A conformationally constrained short peptide designed to target a protein-protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors. Copyright © 2020 American Chemical Society.
- Find related publications in this database (Keywords)
- Constrained peptides
- dimerization hotspot
- dimerization inhibitors
- HIV reverse transcriptase