Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Bravo, A; de Lucio, H; Sánchez-Murcia, PA; Jiménez-Ruiz, A; Petrone, PM; Gago, F; Cortés Cabrera, A.
Identification of NEK3 and MOK as novel targets for lithium.
Chem Biol Drug Des. 2019; 93(5):965-969
Doi: 10.1111/cbdd.13487
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Sánchez Murcia Pedro Alejandro
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- Abstract:
- Lithium ion, commonly used as the carbonate salt in the treatment of bipolar disorders, has been identified as an inhibitor of several kinases, including Glycogen Synthase Kinase-3β, for almost 20 years. However, both the exact mechanism of enzymatic inhibition and its apparent specificity for certain metalloenzymes are still a matter of debate. A data-driven hypothesis is presented that accounts for the specificity profile of kinase inhibition by lithium in terms of the presence of a unique protein environment in the magnesium-binding site. This hypothesis has been validated by the discovery of two novel potential targets for lithium, namely NEK3 and MOK, which are related to neuronal function. © 2019 John Wiley & Sons A/S.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, Neoplasm - chemistry
- Antigens, Neoplasm - metabolism
- Binding Sites -
- Glycogen Synthase Kinase 3 beta - chemistry
- Glycogen Synthase Kinase 3 beta - metabolism
- Humans -
- Inhibitory Concentration 50 -
- Ions - chemistry
- Lithium - chemistry
- Lithium - metabolism
- Magnesium - chemistry
- Magnesium - metabolism
- Mitogen-Activated Protein Kinases - chemistry
- Mitogen-Activated Protein Kinases - metabolism
- Molecular Dynamics Simulation -
- NIMA-Related Kinases - chemistry
- NIMA-Related Kinases - metabolism
- Protein Structure, Tertiary -
- Find related publications in this database (Keywords)
- axonal growth
- bipolar disorder
- GSK3B
- lithium
- MOK
- NEK3