Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
de Castro, S; Fernández-Cureses, G; Andrei, G; Snoeck, R; Sánchez-Murcia, PA; Korba, B; Gago, F; Balzarini, J; Camarasa, MJ.
Conservation of antiviral activity and improved selectivity in PMEO-DAPym upon pyrimidine to triazine scaffold hopping.
Antiviral Res. 2015; 122(1):64-68
Doi: 10.1016/j.antiviral.2015.08.006
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Sánchez Murcia Pedro Alejandro
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- Abstract:
- Acyclic nucleoside phosphonates incorporating 2,4-diaminotriazine (DAT) as a 5-aza-analog of the 2,4-diamino-pyrimidine (DAPym) nucleobase present in PMEO-DAPyms have been synthesized. The lead PMEO-DAT is as inhibitory against HIV, HBV, MSV and VZV replication as the parent PMEO-DAPym and equally inefficient at markedly affecting replication of HSV-1, HSV-2 and HCMV. A rationale for this similar biological profile is proposed on the basis of structural differences in the active site of the viral DNA polymerases. PMEO-DAT is, however, more selective because, unlike PMEO-DAPym, it does not stimulate secretion of β-chemokines in cultured PBMC. Copyright © 2015 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-HIV Agents - chemical synthesis
- Anti-HIV Agents - pharmacology
- Antiviral Agents - chemical synthesis
- Antiviral Agents - pharmacology
- Cells, Cultured -
- Chemokines, CC - immunology
- Chemokines, CC - metabolism
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- Polymerase inhibitors
- Antivirals
- Triazine
- Phosphonates
- Scaffold hopping