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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Wedel, S; Martic, I; Hrapovic, N; Fabre, S; Madreiter-Sokolowski, CT; Haller, T; Pierer, G; Ploner, C; Jansen-Dürr, P; Cavinato, M.
tBHP treatment as a model for cellular senescence and pollution-induced skin aging.
Mech Ageing Dev. 2020; 190: 111318-111318. Doi: 10.1016/j.mad.2020.111318 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Madreiter-Sokolowski Corina
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Abstract:: Accumulation of senescent cells promotes the development of age-related pathologies and deterioration. In human skin, senescent cells potentially impair structure and function by secreting a mixture of signaling molecules and proteases that influence neighboring cells and degrade extracellular matrix components, such as elastin and collagen. One of the key underlying mechanisms of senescence and extrinsic skin aging is the increase of intracellular reactive oxygen species and resulting oxidative stress. Tert-butyl hydroperoxide (tBHP) is a known inducer of oxidative stress and cellular damage, acting at least in part by depleting the antioxidant glutathione. Here, we provide a detailed characterization of tBHP-induced senescence in human dermal fibroblasts in monolayer culture. In addition, results obtained with more physiological experimental models revealed that tBHP treated 3D reconstructed skin and ex vivo skin developed signs of chronic tissue damage, displaying reduced epidermal thickness and collagen fiber thinning. We, therefore, propose that tBHP treatment can be used as a model to study the effects of extrinsic skin aging, focusing mainly on the influence of environmental pollution. Copyright © 2020 Elsevier B.V. All rights reserved.
Find related publications in this database (Keywords): oxidative stress; cigarette smoke; epidermal thinning; collagen degradation