Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Harutyunyan, AS; Muradyan, AA; Badalyan, AR; Babloyan, AS; Kalenteryan, HZ; Sargsyan, KV.
THE BIOMARKERS FOR EARLY PREDICTION AND DIAGNOSE FOR NECROTIZING ENTEROCOLITIS IN NEWBORNS.
NEW ARMEN MED J. 2020; 14(3): 4-11.
Web of Science
- Co-Autor*innen der Med Uni Graz
- Sargsyan Karine
- Altmetrics:
- Abstract:
- Necrotizing enterocolitis is a devastating disease that affects mostly the intestine of premature infants. The wall of the intestine is damaged by hypoxia, and bacteria are invaded, which cause local inflammation and infection that can ultimately destroy with necrosis the wall of the intestine. Such bowel wall destruction can lead to perforation of the intestine and spillage of stool into the infant's abdomen, which can result in an overwhelming infection and death. The clinical presentation of necrotizing enterocolitis includes variable signs, which are often non-specific for gastrointestinal dysfunction. The clinical diagnosis of necrotizing enterocolitis is currently made based on a combination of clinical, laboratory, and instrumental (ultrasound and radiologic) findings. The preventive multi-modal 3-component necrotizing enterocolitis prophylaxis scheme was implemented for necrotizing enterocolitis treatment in December of 2016 in Neonates Intensive Care Unit of "Muratsan" clinical complex of Yerevan State Medical University resulted in significantly reduced necrotizing enterocolitis-associated morbidity and mortality. Necrotizing enterocolitis is severe disease of gastrointestinal tract, yet its early symptoms are non-specific, easily interchangeable with sepsis. Therefore, reliable biomarkers for early diagnostics are needed in clinical practice. One of the promising trends in early diagnosis of necrotizing enterocolitis is use of biomarkers. The biomarkers used in prognosis and diagnosis of necrotizing enterocolitis are relative nonspecific as other noninvasive and less invasive methods. Amongst variety of biomarkers molecules, based on literature, one of the most promising for necrotizing enterocolitis seems to be intestinal fatty acid-binding protein. In modern days, biomarkers widely used for diagnose and prediction in many diseases. Necrotizing enterocolitis is one of the most severe acquired diseases affecting preterm neonates. Early diagnosis remains elusive which continues to prompt human subject studies in the search for necrotizing enterocolitisassociated biomarkers that may provide for early diagnosis or the recognition of high-risk subcohorts with sufficient precision to facilitate preventive measures.
- Find related publications in this database (Keywords)
- necrotizing enterocolitis
- newborns
- biomarkers
- intestinal fatty acid-binding protein