Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Thannesberger, J; Rascovan, N; Eisenmann, A; Klymiuk, I; Zittra, C; Fuehrer, HP; Scantlebury-Manning, T; Gittens-St Hilaire, M; Austin, S; Landis, RC; Steininger, C.
Highly Sensitive Virome Characterization of Aedes aegypti and Culex pipiens Complex from Central Europe and the Caribbean Reveals Potential for Interspecies Viral Transmission.
Pathogens. 2020; 9(9):
Doi: 10.3390/pathogens9090686
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- Co-Autor*innen der Med Uni Graz
- Klymiuk Ingeborg
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- Abstract:
- Mosquitoes are the most important vectors for arthropod-borne viral diseases. Mixed viral infections of mosquitoes allow genetic recombination or reassortment of diverse viruses, turning mosquitoes into potential virologic mixing bowls. In this study, we field-collected mosquitoes of different species (Aedes aegypti and Culex pipiens complex), from different geographic locations and environments (central Europe and the Caribbean) for highly sensitive next-generation sequencing-based virome characterization. We found a rich virus community associated with a great diversity of host species. Among those, we detected a large diversity of novel virus sequences that we could predominately assign to circular Rep-encoding single-stranded (CRESS) DNA viruses, including the full-length genome of a yet undescribed Gemykrogvirus species. Moreover, we report for the first time the detection of a potentially zoonotic CRESS-DNA virus (Cyclovirus VN) in mosquito vectors. This study expands the knowledge on virus diversity in medically important mosquito vectors, especially for CRESS-DNA viruses that have previously been shown to easily recombine and jump the species barrier.
- Find related publications in this database (Keywords)
- mosquito virome
- CRESS-DNA viruses
- CyCV-VN
- insect-specific viruses
- ISV
- BatCV