Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lee, JJ; Wedow, R; Okbay, A; Kong, E; Maghzian, O; Zacher, M; Nguyen-Viet, TA; Bowers, P; Sidorenko, J; Karlsson Linnér, R; Fontana, MA; Kundu, T; Lee, C; Li, H; Li, R; Royer, R; Timshel, PN; Walters, RK; Willoughby, EA; Yengo, L; 23andMe Research Team; COGENT (Cognitive Genomics Consortium); Social Science Genetic Association Consortium; Alver, M; Bao, Y; Clark, DW; Day, FR; Furlotte, NA; Joshi, PK; Kemper, KE; Kleinman, A; Langenberg, C; Mägi, R; Trampush, JW; Verma, SS; Wu, Y; Lam, M; Zhao, JH; Zheng, Z; Boardman, JD; Campbell, H; Freese, J; Harris, KM; Hayward, C; Herd, P; Kumari, M; Lencz, T; Luan, J; Malhotra, AK; Metspalu, A; Milani, L; Ong, KK; Perry, JRB; Porteous, DJ; Ritchie, MD; Smart, MC; Smith, BH; Tung, JY; Wareham, NJ; Wilson, JF; Beauchamp, JP; Conley, DC; Esko, T; Lehrer, SF; Magnusson, PKE; Oskarsson, S; Pers, TH; Robinson, MR; Thom, K; Watson, C; Chabris, CF; Meyer, MN; Laibson, DI; Yang, J; Johannesson, M; Koellinger, PD; Turley, P; Visscher, PM; Benjamin, DJ; Cesarini, D.
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
Nat Genet. 2018; 50(8):1112-1121
Doi: 10.1038/s41588-018-0147-3
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- Co-Autor*innen der Med Uni Graz
- Hofer Edith
- Petrovic Katja-Elisabeth
- Schmidt Helena
- Schmidt Reinhold
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- Abstract:
- Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Cohort Studies -
- Educational Status -
- Female -
- Genome-Wide Association Study - methods
- Humans -
- Male -
- Middle Aged -
- Multifactorial Inheritance -
- Phenotype -
- Polymorphism, Single Nucleotide -