Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Angiari, S; Rossi, B; Piccio, L; Zinselmeyer, BH; Budui, S; Zenaro, E; Della Bianca, V; Bach, SD; Scarpini, E; Bolomini-Vittori, M; Piacentino, G; Dusi, S; Laudanna, C; Cross, AH; Miller, MJ; Constantin, G.
Regulatory T cells suppress the late phase of the immune response in lymph nodes through P-selectin glycoprotein ligand-1.
J Immunol. 2013; 191(11): 5489-5500.
Doi: 10.4049/jimmunol.1301235
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- Führende Autor*innen der Med Uni Graz
- Angiari Stefano
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- Abstract:
- Regulatory T cells (Tregs) maintain tolerance toward self-antigens and suppress autoimmune diseases, although the underlying molecular mechanisms are unclear. In this study, we show that mice deficient for P-selectin glycoprotein ligand-1 (PSGL-1) develop a more severe form of experimental autoimmune encephalomyelitis than wild type animals do, suggesting that PSGL-1 has a role in the negative regulation of autoimmunity. We found that Tregs lacking PSGL-1 were unable to suppress experimental autoimmune encephalomyelitis and failed to inhibit T cell proliferation in vivo in the lymph nodes. Using two-photon laser-scanning microscopy in the lymph node, we found that PSGL-1 expression on Tregs had no role in the suppression of early T cell priming after immunization with Ag. Instead, PSGL-1-deficient Tregs lost the ability to modulate T cell movement and failed to inhibit the T cell-dendritic cell contacts and T cell clustering essential for sustained T cell activation during the late phase of the immune response. Notably, PSGL-1 expression on myelin-specific effector T cells had no role in T cell locomotion in the lymph node. Our data show that PSGL-1 represents a previously unknown, phase-specific mechanism for Treg-mediated suppression of the persistence of immune responses and autoimmunity induction.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Communication - genetics
- Cell Growth Processes - genetics
- Cell Movement - genetics
- Cells, Cultured -
- Dendritic Cells - immunology
- Disease Progression -
- Encephalomyelitis, Autoimmune, Experimental - immunology
- Female -
- Humans -
- Lymph Nodes - pathology
- Lymphocyte Activation - genetics
- Membrane Glycoproteins - genetics
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- Membrane Glycoproteins - metabolism
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