Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Angiari, S; Constantin, G.
Selectins and their ligands as potential immunotherapeutic targets in neurological diseases.
Immunotherapy. 2013; 5(11): 1207-1220.
Doi: 10.2217/imt.13.122
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Angiari Stefano
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- Abstract:
- Selectins are a family of adhesion receptors that bind to highly glycosylated molecules expressed on the surface of leukocytes and endothelial cells. The interactions between selectins and their ligands control tethering and rolling of leukocytes on the vascular wall during the process of leukocyte migration into the tissues under physiological and pathological conditions. In recent years, it has been shown that leukocyte recruitment in the CNS plays a pivotal role in diseases such as multiple sclerosis, ischemic stroke, epilepsy and traumatic brain injury. In this review, we discuss the role of selectins in leukocyte-endothelial interactions in the pathogenesis of neurological diseases, highlighting new findings suggesting that selectins and their ligands may represent novel potential therapeutic targets for the treatment of CNS diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Brain Diseases - immunology
- Brain Diseases - therapy
- Cell Communication - immunology
- Cell Movement - immunology
- Humans -
- Immunotherapy -
- Leukocytes - immunology
- Ligands -
- Multiple Sclerosis - immunology
- Multiple Sclerosis - therapy
- Selectins - immunology
- Find related publications in this database (Keywords)
- disease therapy
- inflammation
- leukocyte trafficking
- rolling
- selectin