Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Paolicelli, RC; Angiari, S.
Microglia immunometabolism: From metabolic disorders to single cell metabolism.
Semin Cell Dev Biol. 2019; 94(10): 129-137.
Doi: 10.1016/j.semcdb.2019.03.012
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Angiari Stefano
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- Abstract:
- Since the observation that obesity-associated low-grade chronic inflammation is a crucial driver for the onset of systemic metabolic disorders such as type 2 diabetes, a number of studies have highlighted the role of both the innate and the adaptive immune system in such pathologies. Moreover, researchers have recently demonstrated that immune cells can modulate their intracellular metabolic profile to control their activation and effector functions. These discoveries represent the foundations of a research area known as "immunometabolism", an emerging field of investigation that may lead to the development of new-generation therapies for the treatment of inflammatory and metabolic diseases. Most of the studies in the field have focused their attention on both circulating white blood cells and leukocytes residing within metabolic tissues such as adipose tissue, liver and pancreas. However, immunometabolism of immune cells in non-metabolic tissues, including central nervous system microglia, have long been neglected. In this review, we highlight the most recent findings suggesting that microglial cells play a central role in metabolic disorders and that interfering with the metabolic profile of microglia can modulate their functionality and pathogenicity in neurological diseases. Copyright © 2019 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Humans -
- Metabolic Diseases - immunology
- Metabolic Diseases - metabolism
- Metabolic Diseases - pathology
- Microglia - immunology
- Microglia - metabolism
- Microglia - pathology
- Single-Cell Analysis -
- Find related publications in this database (Keywords)
- Microglia
- Metabolism
- Immunometabolism
- Metabolic diseases
- Inflammation