Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Lapilla, M; Gallo, B; Martinello, M; Procaccini, C; Costanza, M; Musio, S; Rossi, B; Angiari, S; Farina, C; Steinman, L; Matarese, G; Constantin, G; Pedotti, R.
Histamine regulates autoreactive T cell activation and adhesiveness in inflamed brain microcirculation.
J Leukoc Biol. 2011; 89(2): 259-267.
Doi: 10.1189/jlb.0910486
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Angiari Stefano
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- Abstract:
- Histamine may contribute to the pathology of MS and its animal model EAE. We explored the effects of histamine and specific HR agonists on activation and migratory capacity of myelin-autoreactive T cells. We show that histamine in vitro inhibits proliferation and IFN-γ production of mouse T cells activated against PLP(139-151). These effects were mimicked by the H1R agonist HTMT and the H2R agonist dimaprit and were associated with reduced activation of ERK½ kinase and with increased levels of cell cycle inhibitor p27Kip-1, both involved in T cell proliferation and anergy. H1R and H2R agonists reduced spontaneous and chemokine-induced adhesion of autoreactive T cells to ICAM-1 in vitro and blocked firm adhesion of these cells in inflamed brain microcirculation in vivo. Thus histamine, through H1R and H2R, inhibits activation of myelin-autoreactive T cells and their ability to traffic through the inflamed BBB. Strategies aimed at interfering with the histamine axis might have relevance in the therapy of autoimmune disease of the CNS.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood-Brain Barrier - immunology
- Brain - blood supply
- Cell Adhesion - immunology
- Cell Proliferation -
- Cells, Cultured -
- Chemotaxis, Leukocyte - immunology
- Female -
- Histamine - analogs & derivatives
- Histamine - pharmacology
- Histamine - physiology
- Histamine Agonists - pharmacology
- Inflammation Mediators - pharmacology
- Inflammation Mediators - physiology
- Lymphocyte Activation - immunology
- Mice -
- Microcirculation - immunology
- Multiple Sclerosis - immunology
- Receptors, Histamine - physiology
- Signal Transduction - drug effects
- Signal Transduction - immunology
- T-Lymphocyte Subsets - immunology
- T-Lymphocyte Subsets - pathology
- Find related publications in this database (Keywords)
- autoimmunity
- EAE
- MS
- cytokine
- chemokine