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Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Angiari, S; O'Neill, LA.
Dimethyl fumarate: targeting glycolysis to treat MS.
Cell Res. 2018; 28(6): 613-615. Doi: 10.1038/s41422-018-0045-3 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Angiari Stefano

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Abstract:

Dimethyl fumarate (DMF) is an immunomodulatory drug used in patients with multiple sclerosis (MS) and psoriasis. Kornberg and colleagues shed new light on DMF activity, demonstrating that it blocks immune cell activation through inhibition of glycolysis via post-transcriptional modification of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), which confirms the pro-inflammatory role of glycolysis and points to potential new targets to treat inflammatory diseases such as MS.

Find related publications in this database (using NLM MeSH Indexing)

Administration, Oral -

Dimethyl Fumarate -

Glycolysis -

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