Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Angiari, S; Constantin, G.
Regulation of T cell trafficking by the T cell immunoglobulin and mucin domain 1 glycoprotein.
Trends Mol Med. 2014; 20(12): 675-684.
Doi: 10.1016/j.molmed.2014.10.003
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Angiari Stefano
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- Abstract:
- Leukocyte trafficking is generally considered the initial stage of any immune response, and it involves a multistep intravascular process including capture, rolling, activation, arrest, crawling, and transmigration. Both capture and rolling are predominantly mediated by selectins, which allow circulating leukocytes to sense activating signals on the endothelium and adhere to vessel walls. In this review, we discuss recent data showing that the T cell immunoglobulin and mucin domain 1 (TIM-1) protein is a major ligand for endothelial P-selectin, mediating T helper (Th) cell Th1 and Th17 trafficking in inflamed tissues. We highlight structural and functional features showing that TIM-1 can be included in the restricted group of major adhesion receptors involved in leukocyte trafficking with a pathophysiological role in inflammation and autoimmunity. Copyright © 2014 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Autoimmunity - immunology
- Disease Models, Animal -
- Hepatitis A Virus Cellular Receptor 1 -
- Humans -
- Inflammation - immunology
- Leukocyte Rolling -
- Ligands -
- Lymphocyte Activation -
- Membrane Glycoproteins - immunology
- Receptors, Virus - immunology
- Selectins - immunology
- T-Lymphocytes - immunology
- Th1 Cells - immunology
- Th17 Cells - immunology
- Find related publications in this database (Keywords)
- leukocyte trafficking
- selectins
- TIM-1
- inflammation
- autoimmunity