Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Angiari, S; Donnarumma, T; Rossi, B; Dusi, S; Pietronigro, E; Zenaro, E; Della Bianca, V; Toffali, L; Piacentino, G; Budui, S; Rennert, P; Xiao, S; Laudanna, C; Casasnovas, JM; Kuchroo, VK; Constantin, G.
TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.
Immunity. 2014; 40(4): 542-553.
Doi: 10.1016/j.immuni.2014.03.004
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- Führende Autor*innen der Med Uni Graz
- Angiari Stefano
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- Abstract:
- Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rolling of T helper 1 (Th1) and Th17, but not Th2 and regulatory T cells on P-selectin. Th1 and Th17 cells lacking the TIM-1 mucin domain showed reduced rolling in thrombin-activated mesenteric venules and inflamed brain microcirculation. Inhibition of TIM-1 had no effect on naive T cell homing, but it reduced T cell recruitment in a skin hypersensitivity model and blocked experimental autoimmune encephalomyelitis. Uniquely, the TIM-1 immunoglobulin variable domain was also required for P-selectin binding. Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell trafficking during inflammatory responses and the induction of autoimmune disease. Copyright © 2014 Elsevier Inc. All rights reserved.
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