Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stradner, MH; Dejaco, C; Zwerina, J; Fritsch-Stork, RD.
Rheumatic Musculoskeletal Diseases and COVID-19 A Review of the First 6 Months of the Pandemic.
Front Med (Lausanne). 2020; 7: 562142-562142.
Doi: 10.3389/fmed.2020.562142
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- Führende Autor*innen der Med Uni Graz
- Stradner Martin Helmut
- Co-Autor*innen der Med Uni Graz
- Dejaco Christian
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- Abstract:
- In December 2019, a cluster of severe pneumonia was observed in China, with the subsequent discovery of a new beta-coronavirus (SARS-CoV-2) as the causative agent. The elicited disease COVID-19 is characterized by fever, dry cough, myalgia, or fatigue and has a favorable outcome in the majority of cases. However, in some patients COVID-19 leads to severe pneumonia and sepsis with subsequent respiratory failure and gastrointestinal, hematological, neurological, and cardiovascular complications. A higher risk of infection is intrinsic to active rheumatic and musculoskeletal diseases (RMD) and the use of biological disease modifying anti-rheumatic drugs (DMARDs). With an increasing number of reports on COVID-19 in RMD patients, we are beginning to appraise their risks. In this review, we summarize the published cases of COVID-19 infections in RMD patients, including patients with inflammatory arthritis and connective tissue diseases as well as anti-phospholipid syndrome and Kawasaki syndrome. Overall, patients with inflammatory arthritis do not seem to be at a higher risk for infection or a severe course of COVID-19. Risk for critical COVID-19 in patients with systemic inflammatory diseases such as SLE or vasculitis might be increased, but this needs further confirmation. Furthermore, we summarize the data on DMARDs used to fight SARS-CoV-2 infection and hyperinflammation. Copyright © 2020 Stradner, Dejaco, Zwerina and Fritsch-Stork.
- Find related publications in this database (Keywords)
- COVID-19
- SARS-CoV-2
- rheumatic and musculoskeletal disease
- rheumatoid arthritis
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- Kawasaki disease
- hydroxychloroquine
- IL-6