Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hecking, M; Sharif, A; Eller, K; Jenssen, T.
Management of post-transplant diabetes: immunosuppression, early prevention, and novel antidiabetics.
Transpl Int. 2021; 34(1):27-48
Doi: 10.1111/tri.13783
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Eller Kathrin
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- Abstract:
- Post-transplant diabetes mellitus (PTDM) shows a relationship with risk factors including obesity and tacrolimus-based immunosuppression, which decreases pancreatic insulin secretion. Several of the sodium-glucose-linked transporter 2 inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonists (GLP1-RAs) dramatically improve outcomes of individuals with type 2 diabetes with and without chronic kidney disease, which is, as heart failure and atherosclerotic cardiovascular disease, differentially affected by both drug classes (presumably). Here, we discuss SGLT2is and GLP1-RAs in context with other PTDM management strategies, including modification of immunosuppression, active lifestyle intervention, and early postoperative insulin administration. We also review recent studies with SGLT2is in PTDM, reporting their safety and antihyperglycemic efficacy, which is moderate to low, depending on kidney function. Finally, we reference retrospective case reports with GLP1-RAs that have not brought forth major concerns, likely indicating that GLP1-RAs are ideal for PTDM patients suffering from obesity. Although our article encompasses PTDM after solid organ transplantation in general, data from kidney transplant recipients constitute the largest proportion. The PTDM research community still requires data that treating and preventing PTDM will improve clinical conditions beyond hyperglycemia. We therefore suggest that it is time to collaborate, in testing novel antidiabetics among patients of all transplant disciplines.
- Find related publications in this database (using NLM MeSH Indexing)
- Diabetes Mellitus - administration & dosage
- Diabetes Mellitus, Type 2 - administration & dosage
- Humans - administration & dosage
- Hypoglycemic Agents - therapeutic use
- Immunosuppression - administration & dosage
- Immunosuppressive Agents - therapeutic use
- Kidney Transplantation - administration & dosage
- Postoperative Complications - administration & dosage
- Retrospective Studies - administration & dosage
- Risk Factors - administration & dosage
- Find related publications in this database (Keywords)
- diabetes mellitus
- type 2
- retrospective studies
- prospective studies
- glucagon‐
- like peptide‐
- 1 receptor
- glucose
- hypoglycemic agents
- immunosuppression
- cardiovascular diseases
- insulin
- renal insufficiency
- chronic
- atherosclerosis