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SHR Neuro Cancer Cardio Lipid Metab Microb

Lang, S; Brandau, S; Marchesi, JR; Jablonska, J; Thurnher, D; Mattheis, S; Buer, J; Hussain, T.
[The microbiome in head and neck tumors-initial findings and outlook].
HNO. 2020; 68(12):905-910 Doi: 10.1007/s00106-020-00950-w
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Co-authors Med Uni Graz: Thurnher Dietmar
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Abstract:: Technical progress in molecular biology has allowed for a more detailed analysis of the composition of the human microbiome in recent years. Inter- and intraindividual differences in microbiome composition have been demonstrated, which in part correlate with the occurrence of certain diseases. For some of the so-called oncomicrobes, a direct relationship between their effect on the host organism and carcinogenesis has been demonstrated, predominantly for gastrointestinal cancers. Initial results for head and neck cancer show inter- and intraindividual differences in the local microbiota of the tumor environment, with certain bacterial strains over- or underrepresented. Our results confirm these findings, e.g., by showing a relative abundance of fusobacteria in tumor tissue while streptococci were relatively reduced. Currently available results show a high degree of inter- and intraindividual variation, thus requiring larger patient cohorts for functional analyses.
Find related publications in this database (using NLM MeSH Indexing): Head and Neck Neoplasms -; Humans -; Microbiota -
Find related publications in this database (Keywords): Host microbial interactions; Microbiota; Head and neck neoplasms; Immunotherapy; Microbiome