Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Stattin, M; Haas, AM; Ahmed, D; Stolba, U; Graf, A; Krepler, K; Ansari-Shahrezaei, S.
Detection rate of diabetic macular microaneurysms comparing dye-based angiography and optical coherence tomography angiography.
Sci Rep. 2020; 10(1):16274-16274 Doi: 10.1038/s41598-020-73516-z [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Ansari Shahrezaei Siamak
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Diabetic maculopathy (DM) is a microvascular dysfunction clinically characterized by microaneurysms (MA) leading to edema and central visual deprivation. This prospective explorative study investigated 27 eyes of 17 patients with DM by fluorescein/indocyanine green angiography (FA/ICGA; SPECTRALIS HRA-OCT, Heidelberg Engineering) and by swept source-optical coherence tomography angiography (SS-OCTA; DRI-OCT Triton Plus, Topcon) to identify clinically relevant MAs. The SS-OCTA cubes were split into the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) according to the automated segmentation. The images of all modalities were superimposed for alignment by an Early Treatment Diabetic Retinopathy Study grid overlay and compared to each other. In total, the mean number of MAs in FA was 33.4 ± 22 (standard deviation) (median 27.5 [q1:21.75;q3:38.25]), in ICGA 24.9 ± 16.9 (17.5 [14;35]), in the SCP 6.5 ± 3.7 (5.5 [3.75;9.25]) and in the DCP 18.1 ± 10.5 (18.5 [10.75;23.5]). Mixed effects models between ICGA and the DCP were borderline significant (p = 0.048; 95% confidence interval 0.21 to 13.49), whereas all other imaging methods differed significantly. Quantitative analysis of MAs in DM showed a plausible agreement between ICGA and the DCP in SS-OCTA. These findings contribute to the imaging methodology in DM.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Angiography - methods; Coloring Agents -; Diabetic Retinopathy - diagnosis; Diabetic Retinopathy - diagnostic imaging; Female -; Fluorescein -; Humans -; Indocyanine Green -; Macula Lutea - blood supply; Macula Lutea - diagnostic imaging; Male -; Microaneurysm - diagnosis; Microaneurysm - diagnostic imaging; Middle Aged -; Prospective Studies -; Retinal Vessels - diagnostic imaging; Tomography, Optical Coherence - methods