Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Zweiker, D; Sieghartsleitner, R; Fiedler, L; Toth, GG; Luha, O; Stix, G; Gabriel, H; Vock, P; Lileg, B; Strouhal, A; Delle-Karth, G; Pfeffer, M; Aichinger, J; Tkalec, W; Steinwender, C; Sihorsch, K; Binder, RK; Rammer, M; Barbieri, F; Mueller, S; Verheyen, N; Ablasser, K; Zirlik, A; Scherr, D.
Indications and Outcome in Patients Undergoing Left Atrial Appendage Closure-The Austrian LAAC Registry.
J Clin Med. 2020; 9(10): Doi: 10.3390/jcm9103274 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Zweiker David
Co-authors Med Uni Graz: Ablasser Klemens; Lileg Brigitte; Scherr Daniel; Sieghartsleitner Raphael; Toth-Gayor Gabor; Verheyen Nicolas Dominik; Zirlik Andreas
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Complete real-world data on the indications and outcomes of left atrial appendage closure (LAAC) outside of clinical trials are rare. In this study, we stratified patients undergoing LAAC by indication groups. This analysis of the national multicentre Austrian LAAC Registry comprised all patients that underwent LAAC up until 2018 at the currently active centres in Austria. The baseline characteristics, procedural details and outcomes between the following indication groups were compared: bleeding as an indication for LAAC ("bleeding" group) vs. thromboembolism despite oral anticoagulation (OAC; "thromboembolism" group) vs. an intolerance to OAC for reasons other than the above ("other" group). The analysis included 186 patients, with 59.7% in the "bleeding" group, 8.1% in the "thromboembolism" group and 32.2% in the "other" group. The CHADS₂ score was the highest in the "thromboembolism" group and the HAS-BLED score was the highest in the "bleeding" group. The procedural outcomes were similar between groups (implantation success, 97.3%), with major complications occurring in 7.0% of patients. One-year survival free from stroke, bleeding or LAAC-associated hospitalisation was 83.9%, 90.0% and 81.4% in the "bleeding", "thromboembolism" and "other" groups, respectively (p = 0.891). In routine clinical practice, LAAC was used in a heterogeneous patient population with atrial fibrillation (AF) and contraindication, inefficacy or intolerance to OAC. The long-term outcome was favourable in all groups.
Find related publications in this database (Keywords): atrial fibrillation; left atrial appendage; registry; stroke; bleeding