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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Koshenov, Z; Oflaz, FE; Hirtl, M; Bachkoenig, OA; Rost, R; Osibow, K; Gottschalk, B; Madreiter-Sokolowski, CT; Waldeck-Weiermair, M; Malli, R; Graier, WF.
The contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis in health and disease - A short revisit.
Mitochondrion. 2020; 55(10):164-173
Doi: 10.1016/j.mito.2020.10.003
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- Leading authors Med Uni Graz
- Graier Wolfgang
- Koshenov Zhanat
- Co-authors Med Uni Graz
- Bachkönig Olaf Arne Georg
- Gottschalk Benjamin
- Hirtl Martin
- Madreiter-Sokolowski Corina
- Malli Roland
- Oflaz Furkan Enes
- Osibow Karin
- Rost René
- Waldeck-Weiermair Markus
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- Abstract:
- Considering the versatile functions attributed to uncoupling protein 2 (UCP2) in health and disease, a profound understanding of the protein's molecular actions under physiological and pathophysiological conditions is indispensable. This review aims to revisit and shed light on the fundamental molecular functions of UCP2 in mitochondria, with particular emphasis on its intricate role in regulating mitochondrial calcium (Ca2+) uptake. UCP2's modulating effect on various vital processes in mitochondria makes it a crucial regulator of mitochondrial homeostasis in health and disease. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (Keywords)
- Mitochondrial calcium homeostasis
- UCP2
- MICU1
- PRMT1
- MCU