Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schwarz, C; Fitschek, F; Primavesi, F; Stättner, S; Margonis, GA; Weiss, MA; Stavrou, GA; Oldhafer, KJ; Kornprat, P; Wundsam, H; Fischer, I; Längle, F; Függer, R; Hauer, A; Klug, R; Kieler, M; Prager, G; Schindl, M; Stremitzer, S; Bodingbauer, M; Sahora, K; Kaczirek, K.
Metachronous hepatic resection for liver only pancreatic metastases.
Surg Oncol. 2020; 35:169-173
Doi: 10.1016/j.suronc.2020.08.005
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- Co-authors Med Uni Graz
- Kornprat Peter
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- Abstract:
- BACKGROUND: The value of liver resection (LR) for metachronous pancreatic ductal adenocarcinoma (PDAC) metastases remains controversial. However, in light of increasing safety of liver resections, surgery might be a valuable option for metastasized PDAC in selected patients. METHODS: We performed a retrospective, multicenter study including patients undergoing hepatectomy for metachronous PDAC liver metastases between 2004 and 2015 to analyze postoperative outcome and overall survival. All patients were operated with curative intent. Patients with oligometastatic metachronous liver metastasis with definitive chemotherapy (n = 8) served as controls. RESULTS: Overall 25 patients in seven centers were included in this study. The median age at the time of LR was 63.8 years (56.9-69.9) and the median number of metastases in the liver was 1 (IQR 1-2). There were eight non-anatomical resections (32%), 15 anatomical minor (60%) and 2 major LR (8%). Postoperative complications occurred in eleven patients (eight Clavien-Dindo grade I complications (32%) and three grade IIIa complications (12%), respectively). The 30-day mortality was 0%. The median length of stay was 8.6 days (IQR 5-11). Median overall survival following LR was 36.8 months compared to 9.2 months in patients with metachronous liver metastasis with chemotherapy (p = 0007). DISCUSSION: Liver resection for metachronous PDAC metastasis is safe and feasible in selected patients. To address general applicability and to find factors for patient selection, larger trials are urgently warranted.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Austria - epidemiology
- Carcinoma, Pancreatic Ductal - pathology, surgery
- Chemotherapy, Adjuvant - administration & dosage
- Female - administration & dosage
- Germany - epidemiology
- Hepatectomy - methods
- Humans - administration & dosage
- Liver Neoplasms - pathology, secondary, surgery
- Male - administration & dosage
- Middle Aged - administration & dosage
- Pancreatic Neoplasms - pathology, surgery
- Postoperative Complications - epidemiology
- Retrospective Studies - administration & dosage
- Survival Rate - administration & dosage
- United States - epidemiology
- Find related publications in this database (Keywords)
- Liver resection
- Metachronous metastasis
- PDAC