Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moser, O; Mueller, A; Eckstein, ML; Ziko, H; Aberer, F; Treiber, G; Unteregger, C; Kojzar, H; Mader, JK; Sourij, C; Pferschy, P; Obermayer, A; Tripolt, N; Sourij, H.
Improved glycaemic variability and basal insulin dose reduction during a running competition in recreationally active adults with type 1 diabetes-A single-centre, prospective, controlled observational study.
PLoS One. 2020; 15(9): e0239091-e0239091.
Doi: 10.1371/journal.pone.0239091
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- Führende Autor*innen der Med Uni Graz
- Moser Othmar
- Müller Alexander
- Co-Autor*innen der Med Uni Graz
- Aberer Felix
- Eckstein Max Lennart
- Kojzar Harald
- Mader Julia
- Pferschy Peter
- Ramirez-Obermayer Anna Maria Antonia
- Sourij Caren
- Sourij Harald
- Treiber Gerlies
- Tripolt Norbert
- Unteregger Christina
- Ziko Haris
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- Abstract:
- To investigate the glycaemic response, macronutrient intake and insulin management in people with type 1 diabetes (T1D) compared to healthy individuals around a running competition. This was a single-centre, prospective, controlled observational study performed in individuals with T1D and healthy people. 24 people (12 T1D) were included in this study (age: T1D 41±12 vs. healthy 38±6 years, females: 3 vs. 6, BMI: 25.53.0 vs. 22.9±2.8 kg/m2). Both groups received an intermittently scanned continuous glucose monitoring (isCGM; FreeStyle Libre 1, Abbott, USA) system to assess glycaemia 24 hours before, during and 24 hours after a running competition. During this period, participants recorded their food intake and insulin administration. Data were analysed via ANOVA and mixed model analyses with post-hoc testing (p≤0.05). For overall glycaemic ranges in comparison of groups, significant differences were found for time in range (T1D 63±21% vs. healthy 89±13%, p = 0.001), time above range (TAR) 1 (T1D 21±15% vs. healthy 0±0%, p<0.001) and TAR 2 (T1D 8 [0-16%] vs. healthy 0±0%, p<0.001). When glycaemic variability was assessed, people with T1D had a higher glycaemic variability compared to healthy individuals (p<0.0001). Basal insulin dose was significantly reduced when compared against the regular pre-study basal insulin dose (pre-study 22±6 vs. pre-competition day 11±9 (-50±41%), p = 0.02; competition day 15±5 (-32± 1%)). People with T1D have impaired glucose responses around a running competition compared to healthy individuals. However, basal insulin dose reductions were sufficient to prevent further dysglycaemia. drks.de; DRKS00019886.