Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hoenig, M; Roesler, J; Seidel, MG; Albert, MH; Hauck, F; Maecker-Kolhoff, B; Eiz-Vesper, B; Kleinschmidt, K; Debatin, KM; Jacobsen, EM; Furlan, I; Suttorp, M; Schuetz, C; Schulz, AS.
Matched Family Donor Lymphocyte Infusions as First Cellular Therapy for Patients with Severe Primary T Cell Deficiencies.
Transplant Cell Ther. 2021; 27(1):93.e1-93.e8
Doi: 10.1016/j.bbmt.2020.09.037
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Seidel Markus
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- Abstract:
- Patients with primary immunodeficiencies caused by severe defects in T cell immunity are at risk of acquiring life-threatening infections. Cellular therapies are necessary to establish normal T cell function and to allow for long-term survival. This is most commonly achieved by hematopoietic stem cell transplantation (HSCT), but the outcome of this procedure is impaired if active infections are present at the time of HSCT. Donor lymphocyte infusions (DLIs) are a well-established therapeutic strategy following HSCT to treat viral infections, improve donor cell engraftment, or achieve graft-versus-leukemia activity in malignant disease. Here we present a cohort of 6 patients with primary T cell deficiencies who received transfusions of unselected mature donor lymphocytes prior and not directly related to allogeneic HSCT. DLIs obtained from the peripheral blood of HLA-identical (10/10) family donors were transfused without prior conditioning to treat or prevent life-threatening infections. All patients are alive with a follow-up of 0.5 to 16.5 years after the initial T cell administration. Additional cellular therapies were administered in 5 of 6 patients at 0.8 to 15 months after the first DLI. Mild cutaneous graft-versus-host disease (GVHD, stage ≤2) was observed in 3 of 6 patients and resolved spontaneously. We provide evidence that unselected HLA-identical DLIs can effectively prevent or contribute to overcome infections with a limited risk for GVHD in T cell deficient patients. The T cell system established by this readily available source can provide T cell function for years and can serve as a bridge to additional cellular therapies or, in specific conditions, as definite treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Graft vs Host Disease - therapy
- Hematopoietic Stem Cell Transplantation - adverse effects
- Humans - administration & dosage
- Immunotherapy, Adoptive - administration & dosage
- Lymphocyte Depletion - administration & dosage
- T-Lymphocytes - administration & dosage
- Find related publications in this database (Keywords)
- T cell deficiency
- Opportunistic infection
- Donor lymphocyte transfusion
- Matched family donor
- T cell reconstitution
- HSCT