Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cruz, AF; Rohban, R; Esni, F.
Macrophages in the pancreas: Villains by circumstances, not necessarily by actions.
Immun Inflamm Dis. 2020; 8(4):807-824
Doi: 10.1002/iid3.345
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- Co-Autor*innen der Med Uni Graz
- Rohban Rokhsareh
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- Abstract:
- Mounting evidence suggest that macrophages play crucial roles in disease and tissue regeneration. However, despite much efforts during the past decade, our knowledge about the extent of macrophages' contribution to adult pancreatic regeneration after injury or during pancreatic disease progression is still limited. Nevertheless, it is generally accepted that some macrophage features that normally would contribute to healing and regeneration may be detrimental in pancreatic cancer. Altogether, the current literature contains conflicting reports on whether macrophages act as friends or foe in these conditions. In this review, we briefly review the origins of tissue resident and infiltrating macrophages and the importance of cellular crosstalking between macrophages and other resident cells in tissue regeneration. The primary objective of this review is to summarize our knowledge of the distinct roles of tissue resident and infiltrating macrophages, the impact of M1 and M2 macrophage phenotypes, and emerging evidence on macrophage crosstalking in pancreatic injury, regeneration, and disease. Macrophages are involved with various stages of pancreatic cancer development, pancreatitis, and diabetes. Elucidating their role in these conditions will aid the development of targeted therapeutic treatments. © 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
- Find related publications in this database (Keywords)
- diabetes
- monocytes
- macrophages
- pancreatic cancer
- pancreatitis
- regeneration