Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zweiker, R; Eber, B; Schumacher, M; Toplak, H; Klein, W.
Non-dipping related to cardiovascular events in essential hypertensive patients.
ACTA MED AUST. 1994; 21(3): 86-89.
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Zweiker Robert
- Co-Autor*innen der Med Uni Graz
- Schumacher Martin
- Toplak Hermann
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- Abstract:
- About 1 third of all patients with essential hypertension reveal an impaired circadian pattern of blood pressure. This phenomenon called "non-dipping" (i.e. a lack of the normal nocturnal fall in blood pressure) is related to a higher incidence of end-organ damage such as left ventricular hypertrophy. It is the purpose of this study to evaluate, whether or not non-dipping of blood pressure may worsen the prognosis of hypertensive subjects. 116 consecutive hypertensives underwent an ambulatory blood pressure monitoring (ABPM) using the Spacelabs 2000 device. 2 groups were established: Group I (n = 87) were "dippers", group II (n = 29) "non-dippers" showing a diminished or even lack of nocturnal fall in blood pressure. No difference was seen concerning sex, mean 24-hour systolic blood pressure, systolic and diastolic causal blood pressure and heart rate. However, a significant difference in age and mean 24-hour diastolic blood pressure could be observed. In a follow-up investigation after approximately 31 months all patients and/or their physicians were contacted concerning cardiovascular events during the time since the ABPM was performed. In Group I only 1 transient ischemic attack occurred, but in group II 4 patients showed major cardiovascular events: 3 deaths occurred (2 of which caused by myocardial infarction, 1 by apoplexy), while 1 suffered from a transient ischemic attack (p < 0.001). Thus, in essential hypertension non-dipping of blood pressure is associated with an increased occurrence of cardiovascular events, and, therefore, the circadian blood pressure profile should be carefully monitored.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Arousal - physiology
- Blood Pressure - physiology
- Blood Pressure Monitors - physiology
- Cardiovascular Diseases - diagnosis
- Cause of Death - diagnosis
- Circadian Rhythm - physiology
- Female - physiology
- Follow-Up Studies - physiology
- Humans - physiology
- Hypertension - diagnosis
- Male - diagnosis
- Middle Aged - diagnosis
- Risk Factors - diagnosis
- Survival Rate - diagnosis
- Find related publications in this database (Keywords)
- Essential Hypertension
- Ambulatory Blood Pressure Monitoring
- Dippers
- Non-Dippers
- Myocardial Infarction
- Apoplexy
- Circadian Blood Pressure Rhythm