Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Zelin, E; Conforti, C; Giuffrida, R; Deinlein, T; di Meo, N; Zalaudek, I.
Melanoma in pregnancy: certainties unborn.
MELANOMA MANAG. 2020; MMT48
Doi: 10.2217/mmt-2020-0007
[OPEN ACCESS]
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PubMed
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- Co-authors Med Uni Graz
- Kränke Teresa Maria
- Zalaudek Iris
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- Abstract:
- Melanoma diagnosed during childbearing period or up to 1 year after delivery is defined as pregnancy-associated melanoma (PAM). There is some evidence that PAM has worse prognosis if compared with melanoma in nonpregnant women, although literature is still inconclusive. Many biological mechanisms could explain this behavior, such as hormonal and immune status, increased lymphangiogenesis but also delay in diagnostic and therapeutic management. If PAM is suspected, a prompt excisional biopsy under local anesthesia can be performed regardless of the gestational period. Conversely, additional staging procedures (such as sentinel lymph node biopsy or imaging) and systemic therapy are still debatable during pregnancy. A multidisciplinary tailored approach should be preferred, together with exhaustive counseling of the mother.
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