Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stoppacher, S; Scheruebel, S; Üçal, M; Kornmüller, K; Głowacki; E; Schindl, R; Shrestha, R; Schmidt, T; Baumgartner, C; Rienmüller, T.
Modeling External Stimulation of Excitable Cells Using a Novel Light-Activated Organic Semiconductor Technology.
Stud Health Technol Inform. Ebook: dHealth 2020 – Biomedical Informatics for Health and Care. 2020; 271: 9-16.-Studies in Health Technology and Informatics; May, 19; 2020; virtuell (Corona). (ISBN: 978-1-64368-085-9 )
Doi: 10.3233/SHTI200068
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- Co-Autor*innen der Med Uni Graz
- Kornmüller Karin
- Scherübel-Posch Susanne
- Schindl Rainer
- Schmidt Tony
- Shrestha Niroj
- Ücal Muammer
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- Abstract:
- Optoelectronic neurostimulation is a promising, minimally invasive treatment modality for neuronal damage, in particular for patients with traumatic brain injury. In this work, a newly developed optoelectronic device, a so-called photocap, based on light-activated organic semiconductor structures with high spatial and temporal resolution is investigated. To prove and verify the feasibility of this new technology, a mathematical model was developed, simulating the electrical response of excitable cells to photocap stimulation. In the first step, a comprehensive technical review of the device concept was performed, building the basis for setting up the simulation model. The simulations demonstrate that photocaps may serve as a stimulation device, triggering action potentials in neural or cardiac cells. Our first results show that the model serves as a perfect tool for evaluating and further developing this new technology, showing high potential for introducing new and innovative therapy methods in the field of optoelectronic cell stimulation.
- Find related publications in this database (using NLM MeSH Indexing)
- Action Potentials - administration & dosage
- Humans - administration & dosage
- Models, Theoretical - administration & dosage
- Neurons - administration & dosage
- Semiconductors - administration & dosage