Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Harrison, N; Grabmeier-Pfistershammer, K; Graf, A; Schwarzinger, I; Aberle, JH; Stiasny, K; Greinix, H; Rabitsch, W; Kalhs, P; Ramharter, M; Burgmann, H; Forstner, C.
Humoral immune response to tick-borne encephalitis vaccination in allogeneic blood and marrow graft recipients.
NPJ Vaccines. 2020; 5:67-67
Doi: 10.1038/s41541-020-00215-1
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- The aim of this prospective study was to characterize the humoral immune response to TBE vaccination after hematopoietic stem cell transplantation (HSCT). Nineteen adult patients 11-13 months after HSCT and 15 age-matched immunocompetent adults received up to three TBE vaccinations. Antibodies against TBE virus were measured by neutralization test (NT). As primary endpoint, the antibody response (NT titer of ≥10 and at least a twofold increase from baseline 4 weeks after second vaccination) was compared between patients and controls using Fisher exact test. Prior vaccination, 15 (79%) HSCT patients still had detectable neutralizing antibodies. At primary endpoint, the antibody response was significantly lower in patients than in controls (35% versus 93%; p < 0.001). The CD4+ cell count was a predictor for an antibody response in patients (p = 0.019). Interestingly, the majority of HSCT patients still had detectable antibodies prior vaccination. Following vaccination, antibody response in HSCT patients was associated with the CD4+ cell count. © The Author(s) 2020.