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SHR Neuro Cancer Cardio Lipid Metab Microb
Harutyunyan, A; Urlesberger, B; Muradyan, A; Hovhannisyan, M; Badalyan, A; Kalenteryan, H; Haxhija, E; Sargsyan, K; Yenkoyan, K; Babloyan, A.
Introducing multi-modal enteral medication reduced morbidity and mortality associated with necrotising enterocolitis.
Acta Paediatr. 2021; 110(2):458-464
Doi: 10.1111/apa.15466
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- Leading authors Med Uni Graz
- Urlesberger Berndt
- Co-authors Med Uni Graz
- Haxhija Emir
- Sargsyan Karine
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- Abstract:
- AIM: Necrotising enterocolitis (NEC) is still a disease with high morbidity and mortality. The aim of the study was to analyse retrospectively whether the introduction of a multi-modal three-component enteral medication regimen resulted in a change in morbidity and mortality in neonates with NEC. METHODS: When diagnosis of NEC was established, the following multi-modal three-component enteral medication regimen was administered enterally (via nasogastric tube): an antibiotic, an antifungal agent and a probiotic. The primary outcome parameters were intestinal perforation, surgical interventions and mortality during the observational periods. RESULTS: In the study period, 2212 patients were admitted to the NICU, out of which 200 (9%) developed NEC. Significantly fewer infants died in the Intervention Group (13 of 104 infants, 13%) compared to the Control Group (38 of 96 infants, 40%) (P = .0001). No infant in the Intervention Group (0%) presented with an intestinal perforation, as compared to 15 infants (16%) within the Control Group (P = .0001). In the Control Group, 21 infants (22%) needed surgical intervention, whereas 0 (0%) infants needed this in the Intervention Group. CONCLUSION: The introduction of an enteral multi-modal three-component medication regimen resulted in a significant reduction of mortality and of need for surgical intervention in infants suffering from NEC.
- Find related publications in this database (using NLM MeSH Indexing)
- Enteral Nutrition - administration & dosage
- Enterocolitis, Necrotizing - epidemiology
- Humans - administration & dosage
- Infant - administration & dosage
- Infant, Newborn - administration & dosage
- Infant, Premature, Diseases - administration & dosage
- Morbidity - administration & dosage
- Retrospective Studies - administration & dosage
- Find related publications in this database (Keywords)
- enteral therapeutic approach
- morbidity
- mortality
- necrotising enterocolitis
- preterm infants
- term infants