Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moser, O; Ziko, H; Elsayed, H; Hochfellner, DA; Pöttler, T; Mueller, A; Eckstein, ML; Sourij, H; Mader, JK, , Hypo-RESOLVE, Consortium.
People with type 1 diabetes and impaired awareness of hypoglycaemia have a delayed reaction to performing a glucose scan during hypoglycaemia: a prospective observational study.
Diabet Med. 2020; 37(12):2153-2159
Doi: 10.1111/dme.14362
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- Führende Autor*innen der Med Uni Graz
- Moser Othmar
- Co-Autor*innen der Med Uni Graz
- Eckstein Max Lennart
- Elsayed Hesham
- Hochfellner Daniel
- Mader Julia
- Müller Alexander
- Pöttler Tina
- Sourij Harald
- Ziko Haris
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- Abstract:
- AIMS: Considering that people with type 1 diabetes and impaired awareness of hypoglycaemia (IAH) have a delayed perception of hypoglycaemia, the question arises whether they perform scans later in case of hypoglycaemia than people without IAH. We assessed whether time to performing a scan after reaching hypoglycaemia while using a flash glucose monitoring (flash GM) system is different in people with IAH compared with people without IAH. METHODS: Ninety-two people with type 1 diabetes [mean (± sd) age 42 ± 14 years, HbA1c 57 ± 9 mmol/mol] using a flash GM system for 3 months were included. Flash GM data were assessed for time until scan after reaching hypoglycaemia level 1 (< 3.9 mmol/l) and level 2 (< 3.0 mmol/l) and compared for type 1 diabetes with vs. without IAH via unpaired t-test/Mann-Whitney U test (P < 0.05). RESULTS: Significant differences were found only for the delay between reaching hypoglycaemia and scan between people with and without IAH for Gold score [hypoglycaemia level 1: IAH 78 (51-105) min vs. without IAH 63 (42-89) min, P = 0.03; night-time hypoglycaemia level 2: IAH 140 (107-227) min vs. without IAH 96 (41-155) min, P = 0.004] and Pedersen-Bjergaard score [hypoglycaemia level 1: IAH 76 (52-97) min vs. without IAH 54 (38-71) min, P = 0.011; night-time hypoglycaemia level 1: IAH 132 (79-209) min vs. without IAH 89 (59-143) min, P = 0.011; night-time hypoglycaemia level 2: IAH 134 (66-212) min vs. without IAH 80 (37-131) min, P = 0.002). Data are shown as median (i.q.r.). CONCLUSIONS: Time until scan after reaching hypoglycaemia might be an objective assessment tool for IAH, but needs to be investigated comprehensively in future studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Awareness - administration & dosage
- Blood Glucose Self-Monitoring - methods
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- Female - administration & dosage
- Humans - administration & dosage
- Hypoglycemia - chemically induced, diagnosis
- Hypoglycemic Agents - adverse effects
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- Male - administration & dosage
- Middle Aged - administration & dosage
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- Time Factors - administration & dosage