Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Uranues, S; Bretthauer, G; Tomasch, G; Rafolt, D; Nagele-Moser, D; Berghold, A; Kleinert, R; Justich, I; Waldert, J; Koch, H.
A New Synthetic Conduit for the Treatment of Peripheral Nerve Injuries.
World J Surg. 2020; 44(10):3373-3382
Doi: 10.1007/s00268-020-05620-0
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- Führende Autor*innen der Med Uni Graz
- Uranüs Selman
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Justich Ivo
- Kleinert Reinhold
- Koch Horst
- Nagele-Moser Doris
- Tomasch Gordana
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- Abstract:
- Peripheral nerve defects (PND) often cause lifelong physical disability, and the available treatment options are often not satisfactory. PND are usually bridged with an autologous nerve transplant or a nerve guidance conduit (NGC), when coaptation as preferred technique is not possible. The aim of this experimental study was to determine the effectiveness of a novel NGC for regeneration in the treatment of PND. A conduit made of gelatin with an innovative interior structure was tested for the repair of a 6-mm gap versus direct microsurgical suture repair without gap. We found that bridging the defect with this conduit was as effective as direct microsurgical coaptation without a defect. This nerve conduit, effective in bridging neural defects, appears as an alternative to autologous nerve grafts, avoiding the problems related to nerve graft harvesting, host-donor differences in diameter, mismatches in number and pattern of fascicles, cross-sectional shape and area, and morbidity of the donor area.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Atrophy -
- Evoked Potentials, Motor -
- Gait Analysis -
- Gelatin -
- Models, Animal -
- Muscles - innervation
- Muscles - pathology
- Muscles - physiology
- Nerve Regeneration - physiology
- Neurosurgical Procedures - methods
- Peripheral Nerve Injuries - physiopathology
- Peripheral Nerve Injuries - surgery
- Prostheses and Implants -
- Prosthesis Design -
- Random Allocation -
- Sciatic Nerve - injuries
- Sciatic Nerve - physiology
- Swine -
- Swine, Miniature -
- Titanium -