Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kräuter, C; Reiter, U; Reiter, C; Nizhnikava, V; Masana, M; Schmidt, A; Fuchsjäger, M; Stollberger, R; Reiter, G.
Automated mitral valve vortex ring extraction from 4D-flow MRI.
Magn Reson Med. 2020; 84(6):3396-3408
Doi: 10.1002/mrm.28361
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Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Kräuter Corina
- Reiter Ursula
- Co-Autor*innen der Med Uni Graz
- Fuchsjäger Michael
- Reiter Clemens
- Reiter Gert
- Schmidt Albrecht
- Stollberger Rudolf
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- Abstract:
- PURPOSE: To present and validate a method for automated extraction and analysis of the temporal evolution of the mitral valve (MV) vortex ring from MR 4D-flow data. METHODS: The proposed algorithm uses the divergence-free part of the velocity vector field for Q criterion-based identification and tracking of MV vortex ring core and region within the left ventricle (LV). The 4D-flow data of 20 subjects (10 healthy controls, 10 patients with ischemic heart disease) were used to validate the algorithm against visual analysis as well as to assess the method's sensitivity to manual LV segmentation. Quantitative MV vortex ring parameters were analyzed with respect to both their differences between healthy subjects and patients and their correlation with transmitral peak velocities. RESULTS: The algorithm successfully extracted MV vortex rings throughout the entire cardiac cycle, which agreed substantially with visual analysis (Cohen's kappa = 0.77). Furthermore, vortex cores and regions were robustly detected even if a static end-diastolic LV segmentation mask was applied to all frames (Dice coefficients 0.82 ± 0.08 and 0.94 ± 0.02 for core and region, respectively). Early diastolic MV vortex ring vorticity, kinetic energy and circularity index differed significantly between healthy controls and patients. In contrast to vortex shape parameters, vorticity and kinetic energy correlated strongly with transmitral peak velocities. CONCLUSION: An automated method for temporal MV vortex ring extraction demonstrating robustness with respect to LV segmentation strategies is introduced. Quantitative vortex parameter analysis indicates importance of the MV vortex ring for LV diastolic (dys)function.
- Find related publications in this database (using NLM MeSH Indexing)
- Algorithms - administration & dosage
- Blood Flow Velocity - administration & dosage
- Diastole - administration & dosage
- Heart Ventricles - diagnostic imaging
- Humans - administration & dosage
- Magnetic Resonance Imaging - administration & dosage
- Mitral Valve - diagnostic imaging
- Ventricular Function, Left - administration & dosage
- Find related publications in this database (Keywords)
- 4D-flow
- blood flow
- left ventricle
- mitral valve vortex ring
- Q criterion
- vortex parameter