Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zwirner, J; Ondruschka, B; Scholze, M; Schulze-Tanzil, G; Hammer, N.
Mechanical properties of native and acellular temporal muscle fascia for surgical reconstruction and computational modelling purposes.
J Mech Behav Biomed Mater. 2020; 108(8):103833-103833
Doi: 10.1016/j.jmbbm.2020.103833
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hammer Niels
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- Abstract:
- The temporal muscle fascia (TMF) is a widely used graft material and of interest for computational simulations of the temporomandibular joint as well as computational and physical human head models in general. However, reliable biomechanical properties of the TMF are lacking to date. This study provides tensile data of 52 TMFs at an age range of 18 to 94 years. It further investigates, if acellular fascia scaffolds differ from native counterparts in their biomechanical behaviour. Native TMF has a median elastic modulus of 26.2 MPa (acellular: 24.5 MPa), an ultimate tensile strength of 2.9 MPa (acellular: 2.1 MPa), a maximum force of 12.6 N (acellular: 9.9 N) and a strain at failure of 14.1% (acellular: 14.8%). No significant difference was found regarding the properties of native and acellular samples. Elastic modulus and the ultimate tensile strength increased with age but only in the acellular group (p < 0.01). Decorin and fibronectin seemed to be washed out by the acellularization procedure. The absence of cells in acellular TMF samples is not of biomechanical relevance compared to the native state. Acellular TMF is a biomechanically promising scaffold material for graft purposes, which can be retrieved easily due to its superficial location. Copyright © 2020 Elsevier Ltd. All rights reserved.
- Find related publications in this database (Keywords)
- Acellularization
- Mechanical properties
- Osmotic stress protocol
- Temporal fascia
- Uniaxial tensile testing