Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Muster, V; Gary, T.
Incidence, Therapy, and Bleeding Risk-Cancer- Associated Thrombosis in Patients with Glioblastoma.
Cancers (Basel). 2020; 12(6):
Doi: 10.3390/cancers12061354
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- Führende Autor*innen der Med Uni Graz
- Nemecz Viktoria
- Co-Autor*innen der Med Uni Graz
- Gary Thomas
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- Abstract:
- Cancer is an independent risk factor for the development of venous thromboembolism (VTE). Glioblastomas are amongst cancer types with the most thrombogenic potential and patients are at a particularly high risk of VTE with an incidence up to 20-30% per year. Currently, major efforts are underway to gain novel insights into risk factors and pathomechanisms to provide a better understanding of development of VTE in patients with primary brain tumors. Treatment of VTE requires therapeutic anticoagulation, which accordingly to recently-published guidelines should be performed using low molecular weight heparin or, in case of low bleeding risk, using a direct oral anticoagulant. However, this can be very challenging due to an increased risk of intracranial hemorrhage in this patient group. Furthermore, limited data are available on the subgroup of patients with primary brain tumors.
- Find related publications in this database (Keywords)
- venous thromboembolism
- glioblastoma
- cancer-associated thrombosis
- anticoagulation
- risk factors
- treatment