Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Herbert, MK; Holzer, P.
Nitric oxide mediates the amplification by interleukin-1 beta of neurogenic vasodilatation in the rat skin.
EUR J PHARMACOL 1994 260: 89-93. Doi: 10.1016/0014-2999(94)90014-0 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz: Herbert Michael K.
Co-Autor*innen der Med Uni Graz: Holzer Peter
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Abstract:: Blood flow in the plantar hindpaw skin of anaesthetized rats was measured by laser Doppler flowmetry. Intraplantar injection of interleukin-1 beta (50 pg) significantly enhanced the hyperaemic response to intraplantar capsaicin (0.3 microgram). Pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-evoked hyperaemia and prevented the facilitatory effect of interleukin-1 beta. Blockade of nitric oxide formation by NG-nitro-L-arginine methyl ester failed to affect the capsaicin-evoked vasodilatation but abolished its amplification by interleukin-1 beta. These data indicate that the enhancement by interleukin-1 beta of the capsaicin-induced hyperaemia involves thin afferent nerve fibres and depends on nitric oxide as essential intermediate.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Arginine - analogs and derivatives; Capsaicin - pharmacology; Female - pharmacology; Humans - pharmacology; Interleukin-1 - pharmacology; NG-Nitroarginine Methyl Ester - pharmacology; Neurons, Afferent - drug effects; Nitric Oxide - antagonists and inhibitors; Rats - antagonists and inhibitors; Rats, Sprague-Dawley - antagonists and inhibitors; Regional Blood Flow - drug effects; Research Support, Non-U.S. Gov't - drug effects; Skin - blood supply; Vasodilation - drug effects
Find related publications in this database (Keywords): Afferent Nerve Stimulation; Capsaicin; Cutaneous Hyperemia; Interleukin-1-Beta; Neurogenic Inflammation; Nitric Oxide (No)