Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzer, P; Lippe, IT; Jocic, M; Wachter, C; Erb, R; Heinemann, A.
Nitric oxide-dependent and -independent hyperaemia due to calcitonin gene-related peptide in the rat stomach.
Br J Pharmacol. 1993; 110(1):404-410
Doi: 10.1111/j.1476-5381.1993.tb13824.x
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Co-Autor*innen der Med Uni Graz
- Heinemann Akos
- Lippe Irmgard Theresia
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- Abstract:
- 1. Calcitonin gene-related peptide (CGRP) potently enhances mucosal blood flow in the rat stomach. The aim of this study was to examine whether CGRP also dilates extramural arteries supplying the stomach and whether the vasodilator action of CGRP involves nitric oxide (NO). 2. Rat CGRP-alpha (0.03-1 nmol kg-1, i.v.) produced a dose-dependent increase in blood flow through the left gastric artery (LGA) as determined by an ultrasonic transit time technique in urethane-anaesthetized rats. Blockade of NO synthesis by NG-nitro-L-arginine methyl ester (L-NAME, 20 and 60 mumol kg-1, i.v.) significantly reduced basal blood flow (BF) in the LGA and attenuated the hyperaemic activity of CGRP by a factor of 2.8-4. D-NAME tended to enhance basal BF in the LGA but had no influence on the dilator activity of CGRP. The ability of vasoactive intestinal polypeptide to increase left gastric arterial blood flow remained unaltered by L-NAME. 3. L-NAME (20 and 60 mumol kg-1, i.v.) evoked a prompt and sustained rise of mean arterial blood pressure (MAP) and caused a slight decrease in the hypotensive activity of CGRP. In contrast, D-NAME induced a delayed and moderate increase in MAP and did not influence the hypotensive activity of CGRP. 4. Rat CGRP-alpha dilated the isolated perfused bed of the rat LGA precontracted with methoxamine and was 3 times more potent in this respect than rat CGRP-beta. The dilator action of rat CGRP-alpha in this preparation was not affected by L-NAME or D-NAME (40 microM).(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Anesthesia -
- Animals -
- Arginine - analogs and derivatives
- Blood Pressure - drug effects
- Calcitonin Gene-Related Peptide - pharmacology
- Dose-Response Relationship, Drug - pharmacology
- Female - pharmacology
- Gastric Mucosa - blood supply
- Heart Rate - drug effects
- Hyperemia - chemically induced
- Muscle, Smooth, Vascular - drug effects
- NG-Nitroarginine Methyl Ester - drug effects
- Nitric Oxide - antagonists and inhibitors
- Perfusion - antagonists and inhibitors
- Rats - antagonists and inhibitors
- Rats, Sprague-Dawley - antagonists and inhibitors
- Regional Blood Flow - drug effects
- Stomach - blood supply
- Vasoactive Intestinal Peptide - pharmacology
- Vasodilation - drug effects
- Find related publications in this database (Keywords)
- Calcitonin Gene-Related Peptide (CGRP)
- Vasoactive Intestinal Polypeptide
- Blood Flow
- Rat Stomach
- Gastric Mucosa
- Left Gastric Artery
- Vasodilation
- Hypotension
- Nitric Oxide
- Ng-Nitro-L-Arginine Methyl Ester (L-Name)
- D-Name
- Inhibition of Nitric Oxide